Matt Banahan and Thomas Waldrom have been called into England's Six Nations squad in place of injured pair Luke Narraway and Henry Trinder.
Narraway is currently sidelined with a calf injury, while Trinder is being treated for an ankle problem.
Banahan and Waldrom both featured for England Saxons in Saturday's 23-17 win over Irish Wolfhounds.
England begin their Six Nations campaign against Scotland at Murrayfield on Saturday.