Empoli vs. Hellas Verona (Wednesday, 5.30pm)
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Empoli will welcome Hellas Verona to the Stadio Carlo Castellani in Serie A on Wednesday, with both sides looking to clinch their first win of the season.
The hosts have collected two points from their opening three league matches, while Verona have just one point to their name
We say: Empoli 1-1 Hellas Verona
With both sides low on confidence following a difficult start to the season, we think a cagey contest could result in the spoils being shared on Wednesday.
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Sampdoria vs. Lazio (Wednesday, 5.30pm)
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One of six sides locked on seven points atop the Serie A standings, Lazio look to build on their weekend success with a win against Sampdoria on Wednesday.
While the capital club pulled off a major victory by beating Inter last Friday, Samp were smashed 4-0 by Salernitana and have just one point so far.
We say: Sampdoria 1-3 Lazio
Though Samp will surely get off the mark in terms of goals at the fourth time of asking, their ebbing confidence suggests this is a bad time to welcome in-form Lazio to Marassi. They will defend deep, but may have no answer to the visitors' increasingly fluent 'Sarri-ball'.
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Udinese vs. Fiorentina (Wednesday, 5.30pm)
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Fresh from their first win of the Serie A season, Udinese host misfiring Fiorentina at the Dacia Arena on Wednesday.
While the Friulani saw off promoted Monza last Friday, their Tuscan counterparts posted a third straight goalless draw at the weekend and have not found the net in over 300 minutes of play.
We say: Udinese 1-1 Fiorentina
Given their struggles away from home - and an inability to find the net in recent days - Fiorentina may be forced to settle for a single point against a Udinese side that pose a distinct threat of their own when on top of their game.
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Juventus vs. Spezia (Wednesday, 7.45pm)
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Following successive Serie A draws, Juventus return to action on Wednesday evening, as they host Spezia in Turin.
Held at home by Roma on Saturday, the Bianconeri have taken five points from three games as they begin their quest to regain the Scudetto after two fallow years, while their visitors are just a point behind after drawing 2-2 with Sassuolo.
We say: Juventus 1-0 Spezia
Though their squad feels particularly thin due to injuries, Juventus can continue their supremacy in this match-up of Serie A royalty with provincial hopefuls. It may not be pretty to watch, but the hosts have enough individual quality to decide the game in their favour.
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Napoli vs. Lecce (Wednesday, 7.45pm)
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Having kept their unbeaten record intact at the weekend, Napoli return to home soil on Wednesday, as they host Lecce at Stadio Maradona.
One of six sides locked on seven points at the top of the Serie A standings, the Partenopei take on southern rivals who are yet to taste victory since promotion.
We say: Napoli 1-0 Lecce
Despite their lack of points, Lecce have proved tough enough to withstand pressure and have not lost by more than a one-goal margin. If Napoli opt to rotate their resources, a new-look XI may take a while to gel - but their class in the final third should get the job done.