Facing their second of three successive cup matches, Southampton welcome Blackpool to St Mary's Stadium for the fourth round of the FA Cup on Saturday afternoon.
Nathan Jones's men battled past Crystal Palace 2-1 in the third round to make it this far, while the Tangerines thumped Nottingham Forest 4-1.
Match preview
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Southampton could potentially enter February with a place in the EFL Cup final and fifth round of the FA Cup to their name. Alternatively, the Saints could suffer swift eliminations from both tournaments if results do not go in their favour in the next few days.
Hosting Newcastle United in the first leg of their EFL Cup semi-final on Tuesday evening, Southampton held out for 73 minutes - largely thanks to some wasteful Newcastle finishing - before Joelinton finally got one right, tapping home to seal a 1-0 win for the Magpies.
A one-goal deficit is hardly impossible for Southampton to make up as they prepare for a journey to St James' Park for the second leg on Tuesday, and they already have the know-how when it comes to defeating fellow top-flight teams away from home in cup tournaments.
Indeed, James Ward-Prowse and Adam Armstrong cancelled out Odsonne Edouard's opener as Jones's side beat Palace in the third round of the FA Cup, which marked the start of a three-game winning run for the South Coast side before a 1-0 loss to Aston Villa in the Premier League last weekend.
Southampton are out to reach the fifth round of the FA Cup for the third time in a row this year - having reached the 2020-21 semi-finals and 2021-22 quarters - but losing four of their last five home games does not stand the 20th-placed Premier League side in good stead.
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In the 2021-22 season, it was Nottingham Forest's turn to make waves against Premier League sides in the FA Cup - including a 4-1 thumping of then-champions Leicester City. Fast-forward one year, though, and Blackpool have inflicted an identical defeat on the Tricky Trees.
Marvin Ekpiteta scored the only goal of a relatively low-key first half, but the floodgates opened after the break as Ian Poveda, CJ Hamilton and Jerry Yates all made the net ripple before Ryan Yates netted a late consolation for the shell-shocked visitors.
That thrashing of Forest was in stark contrast to their dismal Championship affairs, as Mick McCarthy takes over a Blackpool side who are now winless in 10 consecutive second-tier matches after going down 2-0 to Watford in their most recent contest on January 14.
The Tangerines - who sit second from bottom in the Championship table - were due to take on Huddersfield Town last week before a frozen pitch led to the postponement of the match, giving them ample time to rest, recuperate and become accustomed to McCarthy's methods.
McCarthy's men are aiming to snap a five-game run without a win on rival territory in a bid to reach the fifth round of the FA Cup for the first time since 2011-12, which also marks the last campaign that they faced Southampton - drawing 2-2 at St Mary's before a 3-0 win on home soil in the Championship.
Team News
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Southampton centre-back Duje Caleta-Car was given an amusing goodbye from Jacob Murphy after being sent off in Tuesday's loss to Newcastle, meaning that he will serve a one-game suspension this weekend before returning for the second leg.
With Jan Bednarek cup-tied as well, Jones will likely bring Romain Perraud into the backline, while Moussa Djenepo will not be risked after suffering a heavy collision with Nick Pope just before half time against Newcastle - leaving the field in a dazed state.
Alex McCarthy, Armel Bella-Kotchap, Juan Larios and Valentino Livramento make up the rest of the hosts' injury concerns, and Jones can be expected to rotate as he prioritises next week's EFL Cup semi-final second leg.
The hosts have also brought in right-back James Bree from Luton Town, but the 25-year-old featured for the Hatters in the third round and therefore cannot make his debut here.
Meanwhile, Blackpool manager McCarthy cannot use the cup-tied Bez Lubala or Owen Dale for Saturday's match, while Rhys Williams has been recalled to Liverpool, and fellow defender Ekpiteta came off with a hamstring issue against Watford and is also sidelined for this one.
Ekpiteta is being kept company in a well-occupied treatment room by Lewis Bridcutt, Lewis Fiorini, Keshi Anderson, Kevin Stewart and Jordan Lawrence-Gabriel, but none of the quintet should be sidelined for too much longer, and Leeds United loanee Ian Poveda should be available again following a groin problem.
Southampton possible starting lineup:
Caballero; Walker-Peters, Lyanco, Salisu, Perraud; Lavia, Maitland-Niles; Edozie, Ward-Prowse, Elyounoussi; A. Armstrong
Blackpool possible starting lineup:
Maxwell; Lyons, Squires, Thorniley, Husband; Lavery, Patino, Carey, Hamilton; Poveda, Madine
We say: Southampton 2-1 Blackpool
Southampton have bigger fish to fry in the Premier League and EFL Cup at the moment, and a classic case of new manager bounce cannot come quickly enough for a woeful Blackpool side.
The Tangerines may have taught Forest a footballing lesson in the third round, but their dismal streak of form makes it difficult to predict a shock result here, and a rotated Southampton team should do just about enough to progress.
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