Manchester United head coach Erik ten Hag has lost his two first-choice defenders to injury ahead of Sunday's Premier League clash with Nottingham Forest at the City Ground.
Both Raphael Varane and Lisandro Martinez were withdrawn in the first leg of their Europa League quarter-final against Sevilla with foot problems; the latter has fractured a metatarsal and will not play again this season, while Varane may not be back until the final couple of weeks of the season.
Marcus Rashford (groin), Donny van de Beek (knee), Tom Heaton and Alejandro Garnacho (both ankle) are also confined to the infirmary, but Luke Shaw (thigh) is closing in on a return, while Scott McTominay is nursing a knock that will need checking over the next 48 hours.
As Varane and Martinez take their places on the sidelines, Victor Lindelof and Harry Maguire - who scored an incredibly unfortunate own goal on Thursday night - will pair up in front of David de Gea.
Tyrell Malacia's spot at left-back should be safe despite also deflecting a cross into his own net, but a well-rested Diogo Dalot should challenge Aaron Wan-Bissaka for his right-back berth.
With Bruno Fernandes suspended for the second leg against Sevilla, the Portuguese should certainly keep his place alongside Casemiro, but two-goal hero Marcel Sabitzer could enjoy a break as Christian Eriksen comes in for his first Premier League start since January.
A distinct lack of senior options up front means that Anthony Martial, Antony and Jadon Sancho should all hold their places, unless Ten Hag gives consideration to a recall for Wout Weghorst amid any lingering concerns over the former's fitness.
Manchester United possible starting lineup: De Gea; Dalot, Lindelof, Maguire, Malacia; Fernandes, Casemiro, Eriksen; Antony, Martial, Sancho
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