Columbus Crew vs. New England (Saturday, 10.00pm)
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MLS Eastern Conference leaders New England Revolution will look to get back to winning ways when they travel to Columbus Crew.
Bruce Arena's side have a two-point lead over Orlando City at the top of the table but have played one game more, while the Crew sit in fifth.
We say: Columbus Crew 1-1 New England Revolution
There will be plenty of anticipation for this game with Columbus Crew in their new stadium for the first time, but New England Revolution will be aiming to be the party crashers. The visitors certainly look the stronger side, but we think the occasion will help the Crew and it will end level.
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DC United vs. Toronto (Saturday, 10.30pm)
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Looking to avoid a sixth consecutive league defeat, Toronto travel to the Audi Field on Saturday to take on DC United.
Meanwhile, the home side will aim to bounce back from a defeat last time out, which ended their three-game unbeaten run.
We say: DC United 1-0 Toronto
The visitors cannot seem to catch a break at the moment as they continue to struggle both home and away. The home side will fancy their chances of claiming all three points in this one and we are backing them to do so.
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Montreal vs. Inter Miami (Sunday, 12.30am)
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Inter Miami will want to put a poor run of form behind them when they face CF Montreal in MLS on Saturday.
The Herons are 12th in the Eastern Conference and are yet to find their feet under Phil Neville, while Montreal are ninth and on the brink of a playoff place.
We say: CF Montreal 0-1 Inter Miami
Inter Miami are desperate to end their losing run and may fancy their chances against a Montreal side also struggling for form. If Gonzalo Higuain plays from the start, Neville's side might just have enough to take all three points.
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Orlando City vs. NY Red Bulls (Sunday, 12.30am)
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Seeking a fourth successive win in the MLS Eastern Conference, second-placed Orlando City prepare to welcome New York Red Bulls to the Exploria Stadium on Sunday.
Oscar Pareja's side marched to a 2-1 success over Inter Miami last time out, while the Red Bulls could only draw 1-1 with Atlanta United.
We say: Orlando City 2-0 New York Red Bulls
Orlando City have only been heading in one direction since their May defeat to the Red Bulls, who just cannot seem to hack it on rival soil.
Furthermore, with both of Struber's goalscorers from that 2-1 win currently unavailable, we cannot see any other result than a fourth straight success for the in-form hosts.
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Chicago Fire vs. Atlanta (Sunday, 1.00am)
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Two sides who have found wins hard to come by in recent weeks face off at the Soldier Field on Sunday as Chicago Fire play host to Atlanta United.
The teams are yet to win any of their last four games apiece and have picked up just three victories between themselves all-season long.
We say: Chicago Fire 1-1 Atlanta United
The two sides have an opportunity to get themselves back on track after a difficult run of form of late. Neither of the sides would be too dissatisfied with a draw and we are backing the tie to end that way.
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Minnesota Utd vs. Earthquakes (Sunday, 1.00am)
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Minnesota United will look to strengthen their position in the Western Conference on Saturday evening when they play host to out-of-form San Jose Earthquakes.
While the home side have put together a lengthy unbeaten streak in the MLS, the visitors have lost five of their last six fixtures.
We say: Minnesota United 2-0 San Jose Earthquakes
With these two sides heading in opposite directions, we can only predict one result. While the Earthquakes will eventually have to improve at both ends of the pitch, they may line up more defensively here, restricting their hosts to a two-goal win.
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Nashville vs. Philadelphia (Sunday, 1.00am)
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Seeking to extend their unbeaten MLS run to 10 matches, Philadelphia Union travel to Nashville SC for this weekend's battle in the Eastern Conference.
Both sides took one point from their most recent encounters, as the hosts rescued a point against Montreal while Philadelphia were held by basement side Chicago Fire.
We say: Nashville SC 1-2 Philadelphia Union
Sunday's battle is unlikely to be a low-scoring affair, and Nashville's unbeaten home record coupled with the Union's away day specialities should make for a fascinating encounter.
The hosts have taken no time at all to settle into life in the MLS, but Philadelphia Union will be more determined than ever to return to winning ways, and we are backing them to do just that.
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Houston vs. Cincinnati (Sunday, 1.30am)
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Houston Dynamo take on FC Cincinnati in the MLS on Saturday.
The two sides last met in July 2019, with Cincinnati winning 3-2 on that occasion.
We say: Houston Dynamo 1-1 FC Cincinnati
We can envisage another draw for Houston when they face Cincinnati on Saturday.
In truth there is very little to split these sides.
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Salt Lake vs. Los Angeles (Sunday, 3.00am)
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Real Salt Lake take on Los Angeles FC in the MLS Western Conference on Saturday.
The two sides are separated by a single point heading into the clash, although Salt Lake do have a game in hand on their forthcoming opponents.
We say: Real Salt Lake 1-2 Los Angeles FC
Bradley's Los Angeles arguably have the stronger squad on paper, so we can envisage them earning a narrow victory on Saturday.
Neither side have been in great form at all of late, so it is unlikely to be a classic encounter.
