Tottenham defender Sergio Reguilon looks set to be out for three weeks with a muscle injury.
The left-back is due to miss Thursday night's game with Liverpool as well as crunch clashes against Chelsea and Manchester City.
It could leave Jose Mourinho in a tight spot for the game against Liverpool as Ben Davies is also a doubt having picked up a knock in Monday's FA Cup win at Wycombe.
Reguilon was an unused substitute in that game, with Mourinho intriguingly choosing to put centre-back Joe Rodon on to replace Davies.
Mourinho alluded to there being an injury issue in his pre-match press conference, but was keen to keep the identity of the player under wraps.
When asked about the fitness of a Ben Davies and Matt Doherty, he said: "Yeah, and we have more problems than that what I'm not going to share.
"You have to wait for tomorrow but we have a little bit of more problems than that."
Reguilon was a summer signing from Real Madrid, arriving on the same day as Gareth Bale's homecoming.
Germany
Switzerland
Hungary
Scotland
Spain
Italy
Croatia
Albania
England
Denmark
Slovenia
Serbia
Austria
France
Netherlands
Poland
Romania
Belgium
Slovakia
Ukraine
Portugal
Turkey
Georgia
Czech Republic