Charlton Athletic manager Chris Powell has made just one change to the side that endured a goalless draw at Brighton & Hove Albion on Tuesday.
Ricardo Fuller comes into the starting lineup having recovered from his shoulder operation, while Lawrie Wilson misses out.
Caretaker boss Neil Redfearn takes charge of Leeds United for the first time and makes four changes after their 2-1 defeat to Derby County at Elland Road on Monday.
Aidy White, Michael Tonge, David Norris and Ross McCormack are all drafted into the first XI, while Luke Varney, El Hadji Diouf, Chris Dawson and Rodolph Austin drop out.
Charlton: Hamer; Solly, Wiggins, Dervite, Morrison; Pritchard, Harriott, Hughes, Jackson; Fuller, Kermorgant
Leeds: Kenny; Peltier, Pearce, Green, Morison, White, Warnock, Tonge, Norris, Byram, McCormack
