Lecce vs. Atalanta (Wednesday, 5.30pm)
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Atalanta BC will be looking to put defeat against league-leaders Napoli behind them as their push for Champions League football continues in Serie A when they travel to face an out-of-form Lecce on Wednesday night.
Gian Piero Gasperini's men have struggled against their rivals at the top of the league standings in recent matches, whereas Lecce have not tasted victory since the middle of September and look set for a relegation fight as they attempt to avoid an immediate return to Serie B.
We say: Lecce 0-1 Atalanta BC
Lecce have been in poor form of late and need to start picking up wins if they are to avoid being relegated to Serie B after just a season in Italy's top flight.
Atalanta have a stunning away record and have only lost to title rivals so far this season, meaning it is hard to see anything other than an away win in this one.
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Sassuolo vs. Roma (Wednesday, 5.30pm)
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Soon after their agonising Rome Derby defeat, Roma attempt to bounce back immediately, as they visit Sassuolo on Thursday evening.
In their final away fixture before Serie A shuts down for the World Cup, the Giallorossi aim to win a fifth road game on the spin, while their hosts have just suffered successive defeats.
We say: Sassuolo 0-1 Roma
With both teams enduring some difficulty putting the ball in the net, a single goal could decide the outcome of a tightly-contested encounter. Roma have proven to be more effective on the road this season, so can edge out their hosts, who are still struggling for momentum.
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Fiorentina vs. Salernitana (Wednesday, 7.45pm)
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After four consecutive wins in all competitions, Fiorentina welcome Salernitana to Stadio Artemio Franchi on Wednesday night as Serie A fast approaches the World Cup break.
Only a point separates the two sides going into this midweek clash, with the visitors enjoying a productive start to the campaign after narrowly avoiding relegation to Serie B last year.
We say: Fiorentina 2-1 Salernitana
Fiorentina are enjoying a good run of form in all competitions as the World Cup break draws closer, but they still have a lot of work to do in order to catch up with those clubs challenging for European places in Serie A.
Salernitana have improved after a woeful start to the campaign and now face two away assignments before the league pauses until January, but a trip to face Italiano's men may be where the good results of late begin to dry up.
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Inter Milan vs. Bologna (Wednesday, 7.45pm)
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Following defeat in last week's Derby d'Italia, Inter Milan sit outside Serie A's top six with just two games remaining until the World Cup break, and they aim for an immediate response when hosting Bologna on Wednesday.
Losing to an ailing Juventus side leaves Inter coach Simone Inzaghi under serious pressure to produce three points at San Siro - particularly against the team which all but ended their Scudetto hopes last term.
We say: Inter Milan 2-1 Bologna
Inter and Bologna have not drawn in Serie A since September 2017 - with the Nerazzurri winning six of the clubs' last nine meetings - and that trend should continue on Wednesday night. For all their flaws, the home side have been reliable on San Siro soil for many months now, so can take all their in-form visitors have to throw at them.
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Torino vs. Sampdoria (Wednesday, 7.45pm)
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Torino and Sampdoria meet in Serie A at the Stadio Olimpico Grande Torino on Wednesday, with both teams looking to bounce back from disappointing defeats on the weekend.
Dejan Stankovic's struggling side were beaten convincingly by Fiorentina in front of their own fans, whereas a shock Bologna comeback denied Torino from taking any points despite their efforts on Sunday.
We say: Torino 2-0 Sampdoria
Torino are marooned in mid-table and need a string of positive results to bridge the gap between themselves and the European places, with the visit of Sampdoria a great fixture to start such a run.
Genova-based Sampdoria desperately need to pick up some points in their final two games before the World Cup, but a trip to Turin on Wednesday night is not a likely destination for success.