Genoa vs. Roma (Sunday, 11.30am)
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Still searching for their first win of the season, Roma will visit Genoa at Stadio Luigi Ferarris for Serie A's Sunday lunchtime kickoff.
A tally of just two points from three games follows the Giallorossi's weak run of form at the end of last term; meanwhile, while their hosts slipped up for the first time just before the international break.
We say: Genoa 2-1 Roma
Needing three points to boost his troops before their Europa League campaign kicks off next week, Daniele De Rossi would have hoped for a more straightforward fixture following the international break.
As Roma's new boys are still settling in - and their coach seems unsure how to use them - Genoa can beat their capital counterparts again.
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Atalanta vs. Fiorentina (Sunday, 2.00pm)
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Both with three points from as many Serie A matches this season, Atalanta BC and Fiorentina will target victory on Sunday, just before kicking off their respective European campaigns.
The teams convene in Bergamo, with the hosts suffering back-to-back defeats before the international break and their visitors yet to win a league game under Raffaele Palladino.
We say: Atalanta BC 2-1 Fiorentina
It will surely be an entertaining encounter at the Gewiss Stadium, as these clubs shared 10 goals in two games last season and have started off on the front foot this term.
Atalanta have the highest xG in Serie A so far (6.2), while Fiorentina have fired in the most shots on target (21) and recorded the best shooting accuracy (64%) - but home advantage should see La Dea shade it.
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Torino vs. Lecce (Sunday, 2.00pm)
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Surprise joint Serie A leaders Torino welcome Lecce to Stadio Olimpico Grande Torino on Sunday, looking to stay level with the clubs atop the table after gameweek four.
The Granata notched consecutive wins before the international to make up for a league-opening draw with AC Milan, and they hope the hiatus does not slow them down going into this weekend's match against a side that claimed their first victory of the 2024-25 campaign in round three.
We say: Torino 1-1 Lecce
Despite Torino's admirable start to the new campaign, Lecce have been better travellers under Gotti, underscored by two road defeats — at San Siro against Milan (3-0) and Inter (2-0) — in six compared to three defeats in seven on their turf.
Thus, the former midfielder will back his side to avoid losing in Turin and avoid a fifth consecutive league loss against the Granata.
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Cagliari vs. Napoli (Sunday, 5.00pm)
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After a dramatic end to August - both on and off the pitch - Napoli return from the international break on Sunday evening, when they meet Cagliari in Sardinia.
While the visitors pulled off an improbable victory last time out, their hosts were beaten by Lecce and have yet to win in Serie A this season.
We say: Cagliari 1-1 Napoli
Even if Napoli are starting to take shape under the demanding management of Antonio Conte, their hosts are set to put up strong resistance and could hold out for a point.
Cagliari can be tough customers on home turf, and their forwards will pose a real threat to the Azzurri's new three-man back line.
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Monza vs. Inter Milan (Sunday, 7.45pm)
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Having made a strong start to their title defence, reigning Serie A champions Inter Milan return from the international break on Sunday evening, as they meet Monza.
Inter face another Lombardy derby after swatting Atalanta BC aside last time out, while their hosts are still seeking a first league win of the 2024-25 campaign.
We say: Monza 1-3 Inter Milan
Boasting impressive squad depth, Inter can afford to change a few faces with greater tests lying ahead. Simone Inzaghi is blessed with options all over the pitch, so his side will see off the modest challenge of Monza.