Arsene Wenger has selected young duo Carl Jenkinson and Francis Coquelin for the crucial match against West Bromwich Albion.
The Gunners, who need a victory to secure Champions League qualification, have called upon Jenkinson to replace the injured Bacary Sagna while Coquelin is set to play left-back.
Theo Walcott returns to the squad and is joined on the bench by Alex Oxlade-Chamberlain.
Roy Hodgson is without Ben Foster for his final game in charge of the Baggies and Martin Fulop will make his first league start for the club in goal.
West Bromwich Albion: Fulop, Jones, McAuley, Olsson, Ridgewell, Cox, Morrison, Mulumbu, Dorrans, Long, Fortune. Subs: Dawson, Shorey, Odemwingie, Scharner, Andrews, Daniels, Hurst
Arsenal: Szczesny, Jenkinson, Vermaelen, Koscielny, Andre Santos, Rosicky, Song, Coquelin, Benayoun, Gervinho, van Persie. Subs: Fabianski, Djourou, Ramsey, Oxlade-Chamberlain, Walcott, Gibbs, Chamakh
