Hull City goalkeeper Steve Harper has been preferred to Allan McGregor for his side's trip to face Southampton.
The introduction of the veteran is one of five changes made by manager Steve Bruce, who has also recalled midfielder Tom Huddlestone.
James Chester, Stephen Quinn and Sone Aluko have also been included, with David Meyler, Gaston Ramirez, Abel Hernandez and Robbie Brady missing out.
Southampton boss Ronald Koeman has also tinkered with his side, with Maya Yoshida, Steven Davis and Saido Mane earning starting roles.
Nathaniel Clyne, James Ward-Prowse and Eljero Elia are the players to drop to the substitutes' bench.
Southampton: K. Davis, Alderweireld, Fonte, Yoshida, Bertrand, Wanyama, Schneiderlin, S. Davis, Mane, Long, Pelle
Subs: Gazzaniga, Clyne, Tadic, Ward-Prowse, Elia, Reed, Targett
Hull City: Harper, Bruce, Chester, Huddlestone, Aluko, N'Doye, Elmohamady, McShane, Quinn, Dawson, Livermore
Subs: McGregor, Rosenior, Brady, Diame, Sagbo, Robertson, Hernandez
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Darren Plant
