Harlequins have made two changes to the side which lost to Saracens last weekend, with Karl Dickson and Mark Lambert coming in for England internationals Danny Care and Joe Marler.
The Exeter Chiefs field a side which includes Tom Johnson, who will make his 50th consecutive Premiership appearance for the Chiefs.
Exeter coach Rob Baxter has made five changes to the starting lineup which lost to the Leicester Tigers, including a debut for Australian international Dean Mumm, who comes replaces skipper Tom Hayes.
Exeter Chiefs: Arscott, Whitten, Dollman, Shoemark, Jess, Steenson, Thomas, Sturgess, Alcott, Rimmer, Mumms, Hanks, Johnson, Baxter
Harlequins: Brown, Steggman, Hopper, Turner-Hall, Monye, Evans, Dickson, Lambert, Gray, Johnston, Kohn, Robson, Guest, Robshaw, Easter
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