Ceara vs. The Strongest (Wednesday, 11.15pm)
Ceara will welcome The Strongest to Castelao for the second leg of their Copa Sudamericana tie, with both sides vying for a place in the quarter finals.
The hosts hold a slender lead ahead of Wednesday's contest after winning 2-1 in Bolivia last week.
We say: Ceara 2-1 The Strongest
The Strongest know that they need to win to have any hope of reaching the quarter finals, and their quest for the win could leave them vulnerable defensively, which Ceara could take advantage of to clinch a second leg victory.
> Click here to read our full preview for this match
Santos vs. Tachira (Thursday, 1.30am)
© Reuters
Santos and Deportivo Tachira will compete in the second leg of their round of 16 Copa Sudamericana fixture on Thursday in a bid to earn a place in the next stage of the competition.
The first game was an even one that finished 1-1, giving neither side an advantage heading into this one, leaving everything to play for.
We say: Santos 1-2 Deportivo Tachira
The fixture last time proved to be closely contested, and that is something that will no doubt be the case again as both teams aim to progress into the next round.
Santos have struggled for form in all competitions as of late, and that lack of confidence is something that could prove to be their downfall here.
> Click here to read our full preview for this match
Melgar vs. Deportivo Cali (Thursday, 1.30am)
After a goalless draw in the first leg of their round of 16 fixture, Melgar will be hosting Deportivo Cali with both teams pushing to earn a place in the next round.
The hosts followed that with another draw, and that is something that they will now be hoping to turn into a victory in front of their own fans.
We say: Melgar 2-0 Deportivo Cali
Melgar might have struggled to create many chances offensively during their previous encounter with Deportivo Cali, but they still head into this game as the favourites to win.
The hosts have been consistent and dominant throughout the campaign in all competitions, and that is something that should help guide them to a victory here.
