Saracens have the chance to top the Aviva Premiership table on Friday night when they play Worcester Warriors at Sixways.
Victory for Mark McCall's team would allow them to overtake Harlequins if the defending champions lose at Bath.
Meanwhile, Worcester will be looking to get back to winning ways after they went down 29-19 at Wasps in the LV= Cup last Sunday.
Joe Carlisle, Nikki Walker, Errie Claassens and Semisi Taulava all return for the hosts, while Neil Best is handed his first start of the campaign.
Full-back Ben Ransom will make his debut for Sarries, who have a number of players missing on international duty including Chris Ashton, Owen Farrell and Mouritz Botha.
However, Matt Stevens, Steve Borthwick, Ernst Joubert and Richard Wigglesworth all come into the starting XV.
Recent form:
Worcester: WWWLWL
Saracens: WWWWWL
Lineups:
Worcester: Pennell, Walker, Matavesi, Carlisle, Claassens, Goode, Hodgson, Jones, Shervington, Andress, Percival, Jones, Best, Kvesic, Taulava
Replacements: Lutui, O'Donnell, Currie, Schofield, Betty, Arr, Grove, Short
Saracens: Ransom, Strettle, Tomkins, Ratuvou, Taylor, Mordt, Wigglesworth, Stevens, George, Nieto, Borthwick, Hargreaves, Wray, Saull, Joubert
Replacements: Smit, Auterac, Romano, Sheriff, Fraser, De Kock, Stanley, Short
Sports Mole says: Sarries to leave Sixways with the spoils
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