Saracens will welcome back Charlie Hodgson to fly half for their Aviva Premiership match against London Wasps on Sunday.
Hodgson is joined in the backline by Chris Wyles, James Short and Kameli Ratuvou, who come in due to others being on international duty.
Owen Farrell, Brad Barritt, Chris Ashton, Mouritz Botha, Alex Goode and Mako Vunipola are all unavailable due to England call-ups, but hooker Schalk Brits will wait until after the match before joining up with South Africa.
Wasps, meanwhile, have made five changes to their side as they look to continue their recent good form.
The changes include a new centre partnership of Chris Bell and Elliot Daly, while Charlie Davies comes in at scrum-half. James Haskell and T. Rhys Thomas complete the changes.
Saracens: Wyles, Strettle, Tomkins, Ratuvou, Short, Hodgson, Wigglesworth; Stevens, Brits, Nieto, Borthwick, Hargreaves, Brown, Saull, Joubert
Replacements: Smit, Auterac, du Plessis, Kruis, Fraser, de Kock, Mordt, Maddock
Wasps: Southwell, Varndell, Daly, Bell, Wade, Robinson, Davies; Payne, Thomas, Taulafo, Launchbury, Wentzel, Johnson, Haskell, Vunipola
Replacements: Lindsay, Swainston, McIntyre, Cannon, Poff, Holmes, Bell, Masi
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