Everton vs. Wolves (Wednesday, 7.30pm)
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Two teams who shipped four goals at the weekend meet at Goodison Park in the Premier League on Wednesday, when Everton host Wolverhampton Wanderers.
With two of the most discontent fanbases in the division, and managers under huge pressure, this is certainly a must-win for both, and one of the most significant in the midweek schedule.
We say: Everton 0-1 Wolverhampton Wanderers
With just seven wins in 35 matches, and one at home all season, Everton are showing no signs of arresting a recent poor run, especially given their very feeble attacking returns.
Wolves have been hapless in defence all season, so it will be an intriguing battle against Everton's poor attack, but their own attacking quality should have enough to penetrate a home defence that is sorely lacking confidence at present.
> Click here to read our full preview for this match
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Man City vs. Nott'm Forest (Wednesday, 7.30pm)
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Currently outside of the Champions League picture let alone the Premier League title race, confidence-depleted champions Manchester City have a seven-game winless run to end when Nottingham Forest arrive at the Etihad on Wednesday night.
Pep Guardiola's troops could not stop the Liverpool juggernaut on Sunday, losing 2-0 to the runaway leaders, while the Tricky Trees edged out Ipswich Town 1-0 to get back to winning ways.
We say: Manchester City 2-1 Nottingham Forest
No team should rock up to the Etihad and resign themselves to defeat during City's unforeseen slump, and a Forest side who have excelled on the road all season long - Arsenal aside - should give Guardiola's team an excellent run for their money.
However, as the Citizens boss can introduce some tricky wingers and creative hubs into a much-changed attack, we can finally envisage the champions arresting their miserable sequence, but only by a narrow margin of victory.
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Newcastle vs. Liverpool (Wednesday, 7.30pm)
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Still on a one-way street to Premier League title glory after the weekend's events, runaway leaders Liverpool pit their wits against Newcastle United at St James' Park on Wednesday evening.
Arne Slot's men effectively knocked Manchester City out of the title race with a 2-0 triumph over the faltering champions on Sunday, one day after the Magpies were pegged back in the final moments of a 1-1 draw with Crystal Palace.
We say: Newcastle United 0-2 Liverpool
Whether Isak is able to shake off his concern in time to face the league leaders only time will tell, but his possible absence will rob the Magpies of their chief threat against the best defence that the Premier League has to offer.
Howe's men have been found wanting in front of goal at St James' Park even with Isak in the lineup anyway, and even with a day's less rest, the Liverpool juggernaut should make light work of their unstable opponents.
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Southampton vs. Chelsea (Wednesday, 7.30pm)
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In-form Chelsea travel the South Coast to face bottom-of-the-table Southampton in the Premier League on Wednesday night.
Enzo Maresca's side continued their excellent run of form with another eye-catching win at the weekend, while the hosts remain cut adrift at the bottom following some controversy on Friday.
We say: Southampton 1-4 Chelsea
Southampton have certainly improved in recent weeks, but their style of play means they will give up chances, and Chelsea have proven they are a clinical force in attack so far this season.
With their big-hitters all in excellent form, Palmer and Nicolas Jackson in particular will see this as a great opportunity to fill their boots again, and possibly move Chelsea into second on their own.
> Click here to read our full preview for this match
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Arsenal vs. Man Utd (Wednesday, 8.15pm)
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Facing one of the biggest threats to their unbeaten start under Ruben Amorim, Manchester United stop over at the Emirates for a Premier League spectacle with Arsenal on Wednesday night.
Both English titans won emphatically in gameweek 13, as the Gunners crushed West Ham United 5-2 before the Red Devils put four past Everton without reply at Old Trafford.
We say: Arsenal 2-0 Manchester United
As potent as Man United have been at their Old Trafford base under Ruud van Nistelrooy and Amorim, their powers often elude them on the road, a bad omen before a visit to Arsenal's Emirates fortress.
Having also lost the effervescent Mainoo and the defensive cornerstone Martinez, Man United should suffer their first setback of the Amorim era against an Arsenal side who have rediscovered their attacking mojo.
History will be written if our prediction comes true, as an Arsenal win would see them beat Man United in four successive league matches for the first time ever.
> Click here to read our full preview for this match
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Aston Villa vs. Brentford (Wednesday, 8.15pm)
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Having surpassed their hosts in the Premier League table, Brentford will aim to pull further clear of ailing Aston Villa when the teams meet on Wednesday evening.
While the Bees brushed Leicester City aside at the weekend, Villa slipped into the bottom half after seeing their long winless streak extended by Chelsea.
We say: Aston Villa 1-1 Brentford
There has been just one clean sheet in six Premier League meetings between Aston Villa and Brentford to date, while Villa are shipping plenty of goals this season and the Bees have scored freely.
Both sides should find the net, then, but they may have to settle for a share of the spoils, which would keep the visitors above their hosts in the table.
> Click here to read our full preview for this match
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