Bafetimbi Gomis starts for Lyon after his winning goal against Saint-Etienne last weekend.
The Frenchman will partner Lisandro Lopez in attack, with Samuel Umtiti and Mouhamadou Dabo replacing Bakary Kone and Aly Cissokho in defence.
Joseph Romeric Lopy comes into the Sochaux midfield in place of Sloan Privat, with Edouard Butin continuing in attack.
Lyon: Lloris, Lovren, Reveillere, Dabo, Umtiti, Grenier, Bastos, Gonalons, Kallstrom, Lopez, Gomis
Sochaux: Richert, Corchia, Banana, Nogueira, Sauget, Boudebouz, Martin, Roudet, Poujol, Lopy, Butin