Italy have seen two of their more experienced players head on holiday as they prepare for Saturday's UEFA Nations League clash with England at Molineux.
Leonardo Bonucci and Andrea Belotti were both named on the bench for the Azzurri's recent win over Hungary, and the duo have now left the camp.
Roberto Mancini has no fresh concerns to report from matchday two, but the tight turnaround should inevitably lead to a number of alterations in all areas of the field.
Giovanni Di Lorenzo is primed to return at right-back in place of Davide Calabria, but Leonardo Spinazzola should be fit enough to hold his place on the opposite flank.
Gianluca Mancini and Alessandro Bastoni ought to form their youthful centre-back pairing in front of Gianluigi Donnarumma, and changes could be rife in the engine room.
Luca Pellegrini could earn a well-deserved rest as Sandro Tonali aims to break back into the XI, while Bryan Cristante is also a candidate to drop out for Manuel Locatelli, with Nicolo Barella continuing in his role.
Gianluca Scamacca was a notable absentee from the squad to face Hungary, but the much-coveted Sassuolo man could return to form a youthful frontline with Wilfried Gnonto and Giacomo Raspadori.
Italy possible starting lineup: Donnarumma; Di Lorenzo, Bastoni, Mancini, Spinazzola; Locatelli, Tonali, Barella; Gnonto, Scamacca, Raspadori
> Click here to see how England could line up for this clash
