The midfielder tore the anterior cruciate ligaments in his left knee during a training session on Thursday.
The 25-year-old Dutchman had only just returned to the Barca set-up following a hamstring problem in pre-season.
Pep Guardiola's side are currently in fourth place in La Liga after Wednesday's 2-2 draw at Valencia.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Barcelona | 18 | 12 | 2 | 4 | 50 | 20 | 30 | 38 |
| 2 | Atletico MadridAtletico | 17 | 11 | 5 | 1 | 31 | 11 | 20 | 38 |
| 3 | Real Madrid | 17 | 11 | 4 | 2 | 37 | 16 | 21 | 37 |
| 4 | Athletic Bilbao | 18 | 9 | 6 | 3 | 27 | 16 | 11 | 33 |
| 5 | Villarreal | 17 | 7 | 6 | 4 | 29 | 28 | 1 | 27 |
| 6 | Mallorca | 18 | 8 | 3 | 7 | 18 | 21 | -3 | 27 |
| 7 | Real Sociedad | 17 | 7 | 4 | 6 | 16 | 11 | 5 | 25 |
| 8 | GironaGirona | 18 | 7 | 4 | 7 | 26 | 25 | 1 | 25 |
| 9 | Osasuna | 17 | 6 | 7 | 4 | 22 | 25 | -3 | 25 |
| 10 | Real BetisBetis | 17 | 6 | 6 | 5 | 20 | 21 | -1 | 24 |
| 11 | Sevilla | 17 | 6 | 4 | 7 | 18 | 23 | -5 | 22 |
| 12 | Rayo Vallecano | 17 | 5 | 6 | 6 | 19 | 20 | -1 | 21 |
| 13 | Celta Vigo | 17 | 6 | 3 | 8 | 25 | 28 | -3 | 21 |
| 14 | Las PalmasLas Palmas | 17 | 5 | 4 | 8 | 22 | 27 | -5 | 19 |
| 15 | Leganes | 17 | 4 | 6 | 7 | 15 | 23 | -8 | 18 |
| 16 | Getafe | 17 | 3 | 7 | 7 | 11 | 14 | -3 | 16 |
| 17 | AlavesAlaves | 17 | 4 | 4 | 9 | 19 | 28 | -9 | 16 |
| 18 | Espanyol | 17 | 4 | 3 | 10 | 16 | 29 | -13 | 15 |
| 19 | Real ValladolidValladolid | 18 | 3 | 3 | 12 | 12 | 37 | -25 | 12 |
| 20 | Valencia | 16 | 2 | 5 | 9 | 14 | 24 | -10 | 11 |
| > La Liga Full Table | |||||||||
