Barcelona will be looking to secure their spot in the last-16 stage of the Copa del Rey when they welcome Segunda B outfit Cultural Leonesa to Camp Nou on Wednesday night.

Barcelona will take a 1-0 advantage into the second leg of the last-32 tie, with Clement Lenglet scoring the only goal of the first leg at the end of October.

Head coach Ernesto Valverde will make changes to his XI following Sunday's 2-0 win over Villarreal in La Liga.

Here, Sports Mole takes a look at how a much-changed Barcelona could line up against the third-tier side on home soil.

Out: Rafinha (knee), Thomas Vermaelen (hamstring), Sergi Roberto (hamstring), Luis Suarez (knee), Sergi Samper (calf), Jasper Cillessen (leg), Samuel Umtiti (knee)
Doubtful: Arthur (abductor tear)

As mentioned, Valverde will ring the changes from the clash with Villarreal on Sunday night. Ruben Semedo and Arturo Vidal are among those who could keep their spots, but there will be a number of alterations.

Carles Alena came off the bench to score against Villarreal and will start, and the 20-year-old is expected to be joined in midfield by Denis Suarez, who is in desperate need of some first-team action.

Munir El Haddadi could be given the chance to lead the attack with support from Ousmane Dembele and Malcom, with Lionel Messi and Philippe Coutinho among those to be given the night off.

The big story could come between the sticks, with 19-year-old Inaki Pena in line to make his first-team debut as number two goalkeeper Jasper Cillessen is still struggling with a foot problem.

Meanwhile, the likes of Juan Miranda and Chumi Brandariz, who were both on the bench against Villarreal, should be handed starting roles.

An extensive injury list still includes the likes of Rafinha, Sergi Roberto, Luis Suarez and Samuel Umtiti.