Reims coach Hubert Fournier has opted for a three-pronged attack, spearheaded by Diego Rigonato, in the clash between two of Ligue 1's mid-table sides.
The Reims attack is completed by Nicolas Fauvergue and Odair Fortes.
Visitors Brest have partnered Israeli striker Eden Ben Basat, who has five league goals, with Larsen Toure, who has two.
Reims: Agassa; Tacalfred, Weber, Souare, Glombard; Krychowiak, Devaux, Ca; Fauvergue, Fortes, Rigonato
Brest: Thebaux; Martial, Mendy, Baysse, Kantari; Lesoimier, Chafni, Sissoko, Licka; Ben Basat, Toure
