Santa Clara vs. Boavista (Saturday, 3.30pm)
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Seeking to pick up successive league victories for the first time since last September, Boavista take a trip to the Estadio de Sao Miguel to lock horns with Santa Clara on Saturday.
Jorge Simao's men, who are without a win in any of their last nine matches across all competitions, will be looking to end this dry spell and begin their surge from the danger zone.
We say: Santa Clara 1-1 Boavista
Boavista have hit their stride since the turn of the year and will be looking to keep the juggernaut rolling. However, given their form away from home, Santa Clara will fancy their chances of getting something on Saturday. We predict a thrilling contest in this one, with both sides settling for a share of the spoils.
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Benfica vs. Casa Pia (Saturday, 6.00pm)
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Casa Pia will be looking to hand Benfica just their second league defeat of the season when they take a trip to the Estadio do Sport Lisboa e Benfica in round 19 of the Primeira Liga on Saturday.
Meanwhile, Roger Schmidt's side will be looking to secure a fourth consecutive victory as they prepare for next week's highly-anticipated Taca de Portugal quarter-final clash against Braga.
We say: Benfica 3-0 Casa Pia
Casa Pia face the stern challenge of squaring off against a rampant Benfica side who are currently firing on all cylinders. As Aguias are unbeaten on home soil this season and, given the gulf in experience and quality between the two sides, we are backing them to ease to a comfortable victory on Saturday.
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Estoril vs. Guimaraes (Saturday, 8.30pm)
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Fresh off the back of ending their eight-game winless run, Vitoria de Guimaraes journey to the Canarinhos to square off against Estoril Praia on Saturday.
The Canarinhos will head into the weekend looking to get one over the visitors, having failed to win any of the last four meetings between the sides since August 2017.
We say: Estoril Praia 1-2 Vitoria de Guimaraes
Buoyed by Monday's victory over Chaves, Vitoria de Guimaraes will head into the weekend with renewed confidence as they resume their push for a place in Europe. Estoril Praia have lost four of their last five matches and we predict that Os Vimaranenses will leave with a slender victory against the floundering hosts.