The 23-year-old has already spent a similar spell at Sheffield Wednesday this season, where he featured four times for the Owls.
He returned to Upton Park at the end of September, but he will now spend the next four weeks at the League One outfit.
Spence could make his debut for the MK Dons in their away fixture at Tranmere Rovers on Saturday.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Walsall | 19 | 12 | 4 | 3 | 35 | 19 | 16 | 40 |
| 2 | Port Vale | 20 | 10 | 6 | 4 | 26 | 19 | 7 | 36 |
| 3 | Crewe AlexandraCrewe | 19 | 9 | 7 | 3 | 24 | 16 | 8 | 34 |
| 4 | AFC Wimbledon | 19 | 10 | 3 | 6 | 31 | 16 | 15 | 33 |
| 5 | Doncaster RoversDoncaster | 20 | 9 | 6 | 5 | 28 | 23 | 5 | 33 |
| 6 | Chesterfield | 20 | 8 | 7 | 5 | 35 | 23 | 12 | 31 |
| 7 | Grimsby Town | 20 | 10 | 1 | 9 | 27 | 30 | -3 | 31 |
| 8 | MK Dons | 18 | 9 | 3 | 6 | 30 | 20 | 10 | 30 |
| 9 | Gillingham | 19 | 9 | 2 | 8 | 20 | 16 | 4 | 29 |
| 10 | Bradford CityBradford | 19 | 7 | 7 | 5 | 24 | 19 | 5 | 28 |
| 11 | Notts County | 19 | 7 | 7 | 5 | 25 | 21 | 4 | 28 |
| 12 | Salford City | 19 | 7 | 6 | 6 | 20 | 19 | 1 | 27 |
| 13 | Cheltenham TownCheltenham | 20 | 7 | 5 | 8 | 27 | 28 | -1 | 26 |
| 14 | Bromley | 19 | 5 | 9 | 5 | 23 | 23 | 0 | 24 |
| 15 | Fleetwood TownFleetwood | 18 | 5 | 8 | 5 | 24 | 23 | 1 | 23 |
| 16 | BarrowBarrow | 19 | 6 | 5 | 8 | 18 | 18 | 0 | 23 |
| 17 | Newport CountyNewport | 19 | 6 | 5 | 8 | 21 | 28 | -7 | 23 |
| 18 | Colchester UnitedColchester | 19 | 4 | 10 | 5 | 23 | 22 | 1 | 22 |
| 19 | Tranmere RoversTranmere | 19 | 5 | 6 | 8 | 14 | 26 | -12 | 21 |
| 20 | Harrogate TownHarrogate | 20 | 6 | 3 | 11 | 17 | 30 | -13 | 21 |
| 21 | Accrington StanleyAccrington | 19 | 4 | 7 | 8 | 26 | 34 | -8 | 19 |
| 22 | Swindon TownSwindon | 20 | 3 | 7 | 10 | 23 | 34 | -11 | 16 |
| 23 | Morecambe | 20 | 3 | 5 | 12 | 19 | 36 | -17 | 14 |
| 24 | Carlisle UnitedCarlisle | 19 | 3 | 5 | 11 | 15 | 32 | -17 | 14 |
| > League Two Full Table | |||||||||
