With the Premier League title and all three relegation places already wrapped up, attention will switch to a fascinating top-four race during the closing stages of the season.
While the FA Cup final is the headline event this weekend, Liverpool also face a must-win game away to West Bromwich Albion, while West Ham United travel to Brighton & Hove Albion.
Champions Manchester City are also in action for the first time since their title triumph was confirmed, taking on Newcastle United on Friday night.
Click play below to watch or listen to Sports Mole Editor Barney Corkhill and Football Editor Matt Law discuss their predictions for all eight Premier League fixtures this weekend.
Watch the full discussion here:
Or you can listen to the full podcast here:
FRIDAY
8pm - Newcastle United vs. Manchester City (0:25)
SATURDAY
12.30pm - Burnley vs. Leeds United (6:18)
3pm - Southampton vs. Fulham (11:43)
8pm - Brighton & Hove Albion vs. West Ham United (16:28)
SUNDAY
12pm - Crystal Palace vs. Aston Villa (22:15)
2.05pm - Tottenham Hotspur vs. Wolverhampton Wanderers (28:04)
4.30pm - West Brom Albion vs. Liverpool (33:24)
7pm - Everton vs. Sheffield United (39:48)
Barney Corkhill
