Southampton boss Claude Puel has made a number of changes for his side's Europa League clash with Hapoel Be'er Sheva.
Puel had already revealed that the quartet of Jose Fonte, Steven Davis, Charlie Austin and Ryan Bertrand had not travelled to Israel, and the French manager has proceeded to make a total of seven alterations to his team.
Jake Hesketh is handed his first start in European football, while there are also starts for Cuco Martina, Maya Yoshida, Jordy Clasie and James Ward-Prowse.
Dusan Tadic, who scored the Saints' second goal against West Ham United on Sunday afternoon, has dropped to the bench.
Hapoel Be'er Sheva: Goresh, Bitton, Vitor, Tzedek, Radi, Nwakaeme, Taha, Maranhao, Melikson, Ogu, Korhut
Southampton: Forster, Yoshida, Clasie, Long, Romeu, Martina, Ward-Prowse, Van Dijk, Redmond, Targett, Hesketh,
Subs: McCarthy, Soares, Tadic, Reed, Hojbjerg, Stephens, Olomola
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