Barcelona midfielder Andres Iniesta could reportedly miss Sunday's La Liga clash with Real Madrid.

The 33-year-old was unable to take part in Barcelona's training session on Thursday, with a calf problem seeing the Spaniard complete "specific work" away from the main group, the club confirmed.

Sunday will prove to be Iniesta's final chance to play in El Clasico as the midfielder prepares to leave Camp Nou at the end of the season following almost 22 years with the club.

Iniesta is still hopeful of being fit for the clash against Los Blancos, according to a number of reports in Spain, but his absence from Thursday's training session has caused concern.

Barcelona wrapped up the La Liga title by beating Deportivo La Coruna last weekend, while Real Madrid are currently battling Atletico Madrid for second position in the table.