A little more than a month on from their last showdown being billed as a title crunch match, Tottenham Hotspur and Liverpool headline gameweek 20 of the season with top four now the priority for both sides.
The 2020-21 campaign enters its second half with a number of other intriguing matches too, including Chelsea beginning life after Frank Lampard with a home game against Wolverhampton Wanderers.
It is top against bottom when Manchester United host Sheffield United, while Southampton will be looking for a second win over Arsenal in the space of three days and Brighton & Hove Albion entertain Fulham in a big game at the bottom.
Click play below to watch or listen to Sports Mole Editor Barney Corkhill and Football Editor Matt Law discuss their predictions for all 10 midweek fixtures.
Watch the full discussion here:
Or you can listen to the full podcast here:
TUESDAY
6pm - Crystal Palace vs. West Ham United (0:32)
6pm - Newcastle United vs. Leeds United (4:20)
8.15pm - West Bromwich Albion vs. Manchester City (8:16)
8.15pm - Southampton vs. Arsenal (11:10)
WEDNESDAY
6pm - Burnley vs. Aston Villa (14:39)
6pm - Chelsea vs. Wolves (19:59)
7.30pm - Brighton & Hove Albion vs. Fulham (25:34)
8.15pm - Everton vs. Leicester City (28:49)
8.15pm - Manchester United vs. Sheffield United (32:48)
THURSDAY
8pm - Tottenham vs. Liverpool (37:08)
Barney Corkhill
