Southampton new boys Pablo Osvaldo and Victor Wanyama have been given places in Mauricio Pochettino's side to face Crystal Palace.
Winger Adam Lallana also starts in the game at St Mary's, as does midfielder Morgan Schneiderlin.
Palace boss Ian Holloway has kept his faith in Marouane Chamakh in attack, who will partner fellow striker Dwight Gayle.
Southampton: Boruc; Clyne, Fonte, Lovren, Shaw, Wanyama, Schneiderlin, S. Davis, Lallana, Lambert, Osvaldo
Crystal Palace: Speroni; Ward, Mariappa, Gabbidon, Moxey, Dikgacoi, Jedinak, Bannan, Kebe, Gayle, Chamakh
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