Real Betis vs. Frankfurt (Wednesday, 5.45pm)
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Real Betis will lock horns with Eintracht Frankfurt at the Estadio Benito Villamarin on Wednesday night for the first leg of their Europa League last-16 contest.
Both sides have struggled for form in recent weeks, with Betis failing to win any of their last four matches across all competitions, while Frankfurt have lost three of their last four games in the Bundesliga.
We say: Real Betis 2-1 Eintracht Frankfurt
Real Betis will be motivated by the prospect of reaching the Europa League final in their home city this season, albeit at the stadium of their rivals Sevilla, but they come up against a Frankfurt side who know what it takes to reach the latter stages of this competition.
Both teams have suffered dips in form recently and although there is little to separate them, the hosts may just edge Wednesday's contest and take a narrow lead into the second leg.
> Click here to read our full preview for this match
Porto vs. Lyon (Wednesday, 5.45pm)
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The Europa League returns on Wednesday night with Porto welcoming Lyon to the Estadio do Dragao for the first leg of their last-16 encounter.
The Dragons head into this contest off the back of a 4-2 Primeira Liga victory against Pacos de Ferreira on Sunday, while Les Gones also netted four times in their last match, winning by a 4-1 scoreline last Friday against Ligue 1 side Lorient.
We say: Porto 2-2 Lyon
Lyon have had two extra days preparation for Wednesday's first leg, but we expect a closely-fought contest to be played out between two of the favourites to go all the way in this year's competition.
The two teams have an eye for goal and we can see the net rippling at both ends of the pitch, but will little to separate them, an entertaining score draw could be on the cards in Portugal.