Pep Guardiola's rotated team picked up a 3-1 victory on Tuesday, a result that extended their winning run to four games in all competitions since the international break.

Southampton, meanwhile, are without a win in the league since the middle of September and they enter Saturday's fixture looking to respond to their record 9-0 loss against Leicester City last Friday.

Here, Sports Mole rounds up City's latest injury and suspension news ahead of welcoming the Saints to the Etihad Stadium.

Leroy Sane

Manchester City's Leroy Sane hobbles off during the Community Shield on August 4, 2019. © Reuters

Status: Out
Type of injury: Knee
Possible return date: Unknown

The German winger picked up a severe ligament injury during the Community Shield in August and he is expected to be out until 2020.

Aymeric Laporte

Manchester City's Aymeric Laporte is stretchered off on August 31, 2019 © Reuters

Status: Out
Type of injury: Knee
Possible return date: Unknown

The French centre-back picked up a similar injury to Sane prior to the September international break. The former Athletic Bilbao defender is unlikely to feature for the first team again before February.

Rodri

Rodri pictured in a Manchester City shirt on August 4, 2019 © Reuters

Status: Out
Type of injury: Thigh
Possible return date: November 23 (vs. Chelsea)

Summer signing Rodri suffered a thigh injury in City's recent Champions League game with Atalanta. While the problem is not thought to be serious, Guardiola confirmed last weekend that the club are anticipating a return after the upcoming international break.

Oleksandr Zinchenko

Status: Out
Type of injury: Knee
Possible return date: December 7 (vs. Man United)

Zinchenko recently underwent a minor operation to sort out some ongoing knee problems and he is likely to return in time for the big Manchester derby in early December.

Angelino

Status: Out
Type of injury: Knock
Possible return date: Unknown

Angelino picked up a knock in City's EFL Cup win over Southampton and he is expected to miss the weekend fixture as the club assess the scale of the problem.