Lecce vs. Sassuolo (Tuesday, 3.00pm)
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After a late collapse cost them two points in Serie A, Lecce return to action on Tuesday, when they welcome Sassuolo to Stadio Via del Mare.
The teams convene for a second-round Coppa Italia contest, with the Salentini having won just one league game this season and their visitors already on course for a quick return to the top flight.
We say: Lecce 1-2 Sassuolo
Sassuolo could compound Lecce's weekend woes, as the Serie B side look strong contenders for promotion this season and have some impressive attacking options.
With their hosts having one eye on a big league game on Friday, the Neroverdi can capitalise and continue their cup run into the third round.
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Cagliari vs. Cremonese (Tuesday, 5.30pm)
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Stuck to the bottom of Serie A, Cagliari hope take a break from their league woes on Tuesday, when they host Cremonese in the second round of the Coppa Italia.
While the Sardinian side have picked up just two points so far, Cremo are flying high in Serie B, just months after they missed out in last season's playoff final.
We say: Cagliari 1-0 Cremonese
It may be a close contest between one team struggling in Serie A and another faring well in Italy's second tier, but Cagliari should come out on top and secure progress in the Coppa Italia.
While Cremonese are in good form, the hosts have plenty of experienced pros who can help steady the ship with an overdue home win.
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Torino vs. Empoli (Tuesday, 8.00pm)
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Both flying high in Serie A, unbeaten pair Torino and Empoli will meet in Turin for a Coppa Italia tie on Tuesday evening.
Something must give, as two teams yet to taste defeat in league or cup go head-to-head, following wins for both at the weekend.
We say: Torino 1-0 Empoli
Empoli will miss out on a last-16 tie with Tuscan rivals Fiorentina, as an impressive Torino side should end their unbeaten run on Tuesday.
The Granata may not be at their best if Paolo Vanoli makes a number of changes, but they have sufficient squad options to secure victory on home turf.
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Ben Knapton
