Ronald Koeman has made three changes for Southampton ahead of their Europa League playoff second-leg clash with FC Midtjylland at the MCH Arena.
James Ward-Prowse, Jay Rodriguez and Cuco Martina start for the Saints in Denmark, taking the place of Cedric Soares, Victor Wanyama and Sadio Mane.
Meanwhile, the hosts make a total of seven changes from their Superliga game at Esbjerg, as they look to make the most of their away goal from the first leg.
Midtjylland secured a 1-1 draw at St Mary's on August 20 as Rodriguez needed a second-half penalty to overturn a Tim Sparv strike on the stroke of half time.
Midtjylland: Dahlin, Nielsen, Lauridsen, Hansen, Sviachenko, Sparv, Andersson, Royer, Poulsen, Sisto, Rasmussen
Subs: Andersen, Jensen, Romer, Hassan, Olsson, Onuachu, Pusic
Southampton: Stekelenburg, Martina, Fonte, Caulker, Yoshida, Targett, Romeu, S. Davis, Ward-Prowse, Pelle, Rodriguez
Subs: K. Davis, Cedric, Long, Mane, Tadic, Reed, Juanmi
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