Aldosivi visit the Estadio Brigadier General Estanislao Lopez to lock horns with Colon on Tuesday aiming to avoid a third defeat in a row.
On the other hand, the home side set out to continue their recent upturn in form having picked up four of the last six points available.
Match preview
Colon recorded their first away point since the opening day following a goalless stalemate against Gimnasia at the Estadio Juan Carmelo Zerillo on Saturday.
Despite being on the back foot for the majority of the contest, Julio Cesar Falcioni's men held firm to secure a hard-earned share of the spoils in La Plata.
Consequently, the Tarpon Fishers have climbed up to 16th place in the Argentine Primera Division table, just two points shy of the top half.
Awaiting them next is the challenge of an opposing outfit who have suffered only one loss in the most recent five encounters between the sides, winning the other four.
Having returned to winning ways on home turf with a 2-1 victory over Velez Sarsfield last time out, Tuesday's hosts will be confident of securing another positive result in front of their fans.
Aldosivi were narrowly beaten 1-0 by Atletico Tucuman when the teams went toe to toe at the Estadio Jose Maria Minella on Saturday morning.
Ramiro Ruiz Rodriguez broke the deadlock in the 14th minute which turned out to be the all-important moment that put Leandro Somoza's men to the sword.
With just four points on the board so far, El equipo de la Ciudad remain bottom of the league standings and are in need of a pick-me-up.
Off the back of six consecutive away defeats across all competitions, Tuesday's hosts will be keen to turn things around on the road starting with the trip to Santa Fe.
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Team News
Patricio Boolsen is now eligible to feature for Aldosivi having served a one-game ban in the defeat to Atletico Tucuman last time out.
Thirty-five-year-old Martin Cauteruccio remains sidelined for the away side and is on course to sit out an eighth game on the bounce.
Facundo Farias will be pushing for a return to the starting XI here after missing Colon's most recent involvement through suspension.
Augusto Schott and Andrew Teuten are both rule out through knee problems, while Cristian Vega continues to battle with a leg injury.
Colon possible starting lineup:
Chicco; Meza, Garces, Goltz, Ojeda; Pierotti, Chicco, Bernardi, Farias; Abila, Rodriguez
Aldosivi possible starting lineup:
Devecchi; Roman, Valentini, Boolsen, Lucero; Meli, Maciel, Kociubinski; Rios, Silva, Martinez
We say: Colon 2-1 Aldosivi
Aldosivi have struggled at both ends of the pitch, and Colon will be looking to heap more misery on their visitors. We are predicting a narrow win for the home side come the sound of the final whsitle.
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