Daniel Pudil, Barry Bannan and Fernando Forestieri have all been named to make their Sheffield Wednesday debuts at Burnley.
The Owls also welcome back skipper Glenn Loovens after the Dutchman recovered from an ankle injury.
Matt Lowton, who has struggled with injury since joining from Aston Villa, could make his first Burnley appearance after being selected on the bench.
However, Lukas Jutkiewicz misses out after damaging his cruciate ligaments.
Burnley: Heaton; Darikwa, Duff, Keane, Mee; Boyd, Jones, Arfield, Kightly, Vokes, Gray
Subs: Gilks, Ward, Hennings, Taylor, Lowton, Long, Anderson
Sheffield Wednesday: Wildsmith; Palmer, Loovens, Lees, Hutchinson; Lee, Pudil, Bannan, Wallace; Nuhiu, Forestieri
Subs: Price, Turner, Semedo, Matias, Helen, Joao, Lopez
