Real Madrid are reportedly planning to sell Isco during the January transfer window.
The 29-year-old has made 343 appearances for Los Blancos since arriving from Malaga in July 2013, winning two La Liga titles, one Copa del Rey and four Champions League trophies in the process.
Isco has struggled for action during the 2021-22 campaign, though, managing just one goal in seven appearances, while he has only featured once in La Liga since the end of September.
The playmaker's contract at Bernabeu is due to expire next June, and according to Mundo Deportivo, Real Madrid are planning to move him on during the January transfer window.
The report claims that Isco's training performances have not impressed Los Blancos boss Carlo Ancelotti, who does not view the Spaniard as part of his plans moving forward.
English giants Arsenal are believed to be interested in the experienced attacker, while Real Betis and Sevilla are thought to be keen to keep him in Spain.