Hector Bellerin, Laurent Koscielny, Nacho Monreal and Aaron Ramsey have all been named in Arsenal's starting lineup for the second leg of the Europa League last-16 tie with AC Milan.
Bellerin is back in action after overcoming a knee injury and makes his first start since taking part in the 3-0 loss to Manchester City on March 1.
Monreal returns from a back problem, while fellow defender Shkodran Mustafi is also in the XI after being passed fit to play despite having limped off with a groin problem in Sunday's 3-0 win over Watford.
Jack Wilshere has earned a starting berth in the middle of the park, while David Ospina is named in goal and Danny Welbeck leads the line.
Alexandre Lacazette and Santi Cazorla remain sidelined, while Pierre-Emerick Aubameyang is ineligible to take part in the Europa League for the Gunners this term.
For Milan, defender Davide Calabria has not travelled with the squad, which means that Gennaro Gattuso has picked former Liverpool forward Fabio Borini to feature at right-back, having started in that position in their 1-0 win over Genoa on Sunday.
Arsenal: Ospina; Bellerin, Mustafi, Koscielny, Monreal; Xhaka, Ramsey; Wilshere, Ozil, Mkhitaryan; Welbeck
Subs: Cech, Chambers, Kolasinac, Elneny, Maitland-Niles, Iwobi, Nketiah
AC Milan: Donnarumma; Bonucci, Romagnoli, Rodriguez, Suso, Kessie, Montolivo, Calhanoglu, Borini, Cutrone, Silva
Subs: Storari, Musacchio, Zapata, Biglia, Bonaventura, Locatelli, Kalinic
