South Africa have finished their innings on 220-8 in the fourth One-Day International at Lord's.
Alistair Cook won the toss and put the Proteas in to bat. However, Graeme Smith and Hashim Amla made a solid start, bringing up their 50 partnership in the 16th over.
It was Jade Dernbach who made the breakthrough, getting rid of Smith for 29 in the 19th over.
Amla was then bowled by Ravi Bopara for 45, before JP Duminy (18) quickly followed him into the pavilion when he was stumped by Craig Kieswetter off the bowling of James Tredwell.
The wickets were quickly tumbling, as Bopara claimed his second when Faf Du Plessis (1) went cheaply after dragging onto his stumps.
AB De Villiers and Dean Elgar then formed a partnership that put 51 runs on the board.
However, De Villiers (39) became the second victim of a Kieswetter when he tried to take on Tredwell and England had South Africa at 166-5.
Tredwell claimed the wicket of Wayne Parnell (5), before Steven Finn removed Elgar (35) in the final over.
Ryan McLaren was also run out by a direct hit from Dernbach to leave England chasing 221 runs for victory.
