The San Francisco 49ers have placed Mario Manningham on injured reserve.
The wide receiver missed the first half of the season while continuing to recover from an ACL reconstruction, and is believed to have suffered a setback to the surgically-repaired knee.
Head coach Jim Harbaugh told reporters: "He's consulting with doctors. We'll do what's in the best interest of his career. He's got input on that. It's really a conversation between doctors and Mario at this point.
"For me to talk about it, I'm not a doctor. To tell you what level of last year or this year, if it's something different. The doctors and Mario are the people to talk to about that."
Manningham will become a free agent at the end of the season.
