Mauricio Pochettino has made two changes to his Southampton team that lost 1-0 at Norwich City two weeks ago.
Young full-back Calum Chambers is replaced by Nathaniel Clyne, while Jay Rodriguez takes the place of James Ward-Prowse.
West Ham United make just one change to their team from the 1-0 loss at home to Stoke City. Ravel Morrison replaces new signing Stewart Downing.
Southampton: Boruc; Clyne, Fonte, Lovren, Shaw; Wanyama, Schneiderlin, Lallana, Rodriguez; Osvaldo, Lambert
West Ham United: Jaaskelainen; Demel, O'Brien, Collins, Reid; Noble, Nolan, Diame; Morrison, Jarvis, Maiga
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