Cadiz vs. Celta Vigo (Saturday, 1.00pm)
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Celta Vigo will be looking to continue their impressive run of form in La Liga when they make the trip to Nuevo Mirandilla on Saturday afternoon to take on Cadiz.
The visitors will enter the match off the back of a 2-0 win over Rayo Vallecano on February 5, while Cadiz suffered a 2-1 defeat to Mallorca last time out to remain in the relegation zone.
We say: Cadiz 1-2 Celta Vigo
Celta's away form this season has been impressive, while Cadiz have struggled at home, so we are finding it difficult to predict anything other than an away victory here. It should be a tight match on Saturday afternoon, but we are expecting the visitors to navigate their way to an important three points.
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Villarreal vs. Real Madrid (Saturday, 3.15pm)
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Real Madrid will be bidding to make it back-to-back wins in La Liga when they make the trip to Estadio de la Ceramica on Saturday afternoon to face Villarreal.
Los Blancos are currently top of the table, six points clear of second-placed Sevilla, while Villarreal occupy sixth spot, three points behind fourth-placed Barcelona ahead of the next set of fixtures.
We say: Villarreal 1-1 Real Madrid
If Benzema was definitely available for this match then we would be backing Real Madrid to win 2-1, but the Frenchman is unlikely to feature, which will be a huge boost for Villarreal. The Yellow Submarine are chasing a top-four finish this term, and we believe that a tight match this weekend will finish all square.
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> How Real Madrid could line up against Villarreal
> Real Madrid injury, suspension list vs. Villarreal
Rayo Vallecano vs. Osasuna (Saturday, 5.30pm)
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Rayo Vallecano will be bidding to return to winning ways when they welcome Osasuna to Estadio de Vallecas on Saturday evening.
The home side are currently ninth in Spain's top flight, boasting 31 points from 22 matches, while Osasuna occupy 12th position, two points behind their opponents this weekend.
We say: Rayo Vallecano 1-1 Osasuna
Osasuna have had longer to prepare for this match, which should aid them on Saturday, especially in the second half. Rayo's home form this season has been excellent, though, so we are finding it difficult to predict a defeat for the capital side, instead settling on a low-scoring draw.
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Atletico vs. Getafe (Saturday, 8.00pm)
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Atletico Madrid will be bidding to return to winning ways in La Liga when they welcome Getafe to Wanda Metropolitano on Saturday night.
Diego Simeone's side will enter the contest off the back of a 4-2 defeat to Barcelona last weekend, while Getafe recorded a 3-0 victory over Levante to move further clear of the relegation zone.
We say: Atletico Madrid 2-1 Getafe
Atletico desperately need to return to winning ways after the loss to Barcelona last time out, and we are expecting the home side to triumph. Getafe have not travelled well this season and could suffer their seventh away La Liga defeat of the campaign at Wanda Metropolitano.