Atletico Madrid will be without Thibaut Courtois and David Villa for their Copa del Rey tie with Real Madrid on Tuesday.

The Rojiblancos host their local rivals at the Vicente Calderon, and Diego Simeone's side will have to turn around their 3-0 deficit from the first leg without the influential duo.

On-loan goalkeeper Courtois has been struggling with a back problem, while former Barcelona striker Villa misses out due to a hamstring strain.

Atletico are unbeaten at home this season.