Manchester United have succumbed to a shock 1-0 defeat at the hands of high-flying Southampton in this afternoon's Premier League clash at Old Trafford.

Manchester United's English defender Tyler Blackett can't reach the shot from Southampton's Serbian midfielder Dusan Tadic as Tadic scores the opening goal during the English Premier League football match between Manchester United and Southampton at Old T © Getty Images

The visitors made a lively start, threatening within the first two minutes after Nathaniel Clyne exchanged passes on the edge of the box before hitting a shot across goal, but his effort flew narrowly wide of the post.

Despite the burst of early action, the game's tempo slowed down as both sides played a patient game in a bid to suss out their opponents.

After just twenty minutes, Southampton suffered a setback when Toby Alderweireld was forced off with a leg problem he suffered after attempting to clear a ball.

United were failing to click in the final third for most of the first half, but stepped it up a gear towards the latter stages when Angel di Maria and Robin van Persie mustered two dangerous chances on goal.

Southampton's Serbian midfielder Dusan Tadic removes his shirt as he celebrates scoring the opening goal during the English Premier League football match between Manchester United and Southampton at Old Trafford in Manchester, north west England, on Janua © Getty Images

The hosts registered their first chance of the second half in the 53rd minute as Wayne Rooney's free kick was headed towards goal by Phil Jones, but the defender's attempt soared over the crossbar.

Southampton proved sturdy in defence, closing down their opponents time after time, and went one better when they took the lead in the 68th minute.

A neat passing move on the edge of the box saw Graziano Pelle hit the post with a low strike, but substitute Dusan Tadic was at hand to roll in the rebound with a tidy finish.

United set about trying to find an equaliser and probed forward at every opportunity, coming close in the 77th minute when Daley Blind's cross from the left almost caught Fraser Forster out, before Juan Mata shot wide moments later.

Southampton, however, were able to see the game out and secure three well-earned points to leapfrog the Red Devils into third place.