Manchester United will be crowned champions of England for the 20th time on Monday night if they beat Aston Villa at Old Trafford.
The Red Devils saw their hopes of clinching the title given a huge boost on Sunday as holders Manchester City were defeated 3-1 at Tottenham Hotspur.
The gap between the two sides now stands at 13 points with 15 more up for grabs before the end of the season.
Meanwhile, a surprise win for struggling Villa at the Theatre of Dreams would see both Reading and Queens Park Rangers relegated from the top flight with four games left to play.
Ashley Young is ruled out for the hosts with an ankle injury, while Paul Scholes could feature following a knee problem.
Gabriel Agbonlahor is expected to overcome a thigh strain for the visitors, who have no fresh injury concerns ahead of the match.
Recent form:
Man Utd: WWLLWD
Villa: LWWLWD
Possible lineups:
Man Utd: De Gea; Rafael, Ferdinand, Vidic, Evra; Valencia, Carrick, Giggs; Kagawa; Rooney, Van Persie
Villa: Guzan; Vlaar, Bennett, Baker, Lowton; N'Zogbia, Westwood, Delph; Agbonlahor; Benteke, Weimann
Sports Mole says: 3-1
