The Honduran was taken off after he had played a significant part in creating the second goal of United's 2-0 victory, scored by Javier Hernandez.
He is now expected to miss up to four weeks, according to the club's official website.
United host Ajax at Old Trafford in the second leg next Thursday.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Liverpool | 15 | 11 | 3 | 1 | 31 | 13 | 18 | 36 |
| 2 | Chelsea | 16 | 10 | 4 | 2 | 37 | 19 | 18 | 34 |
| 3 | Arsenal | 16 | 8 | 6 | 2 | 29 | 15 | 14 | 30 |
| 4 | Nottingham ForestNott'm Forest | 16 | 8 | 4 | 4 | 21 | 19 | 2 | 28 |
| 5 | Manchester CityMan City | 16 | 8 | 3 | 5 | 28 | 23 | 5 | 27 |
| 6 | Bournemouth | 16 | 7 | 4 | 5 | 24 | 21 | 3 | 25 |
| 7 | Aston Villa | 16 | 7 | 4 | 5 | 24 | 25 | -1 | 25 |
| 8 | Fulham | 16 | 6 | 6 | 4 | 24 | 22 | 2 | 24 |
| 9 | Brighton & Hove AlbionBrighton | 16 | 6 | 6 | 4 | 26 | 25 | 1 | 24 |
| 10 | Tottenham HotspurSpurs | 16 | 7 | 2 | 7 | 36 | 19 | 17 | 23 |
| 11 | Brentford | 16 | 7 | 2 | 7 | 32 | 30 | 2 | 23 |
| 12 | Newcastle UnitedNewcastle | 16 | 6 | 5 | 5 | 23 | 21 | 2 | 23 |
| 13 | Manchester UnitedMan Utd | 16 | 6 | 4 | 6 | 21 | 19 | 2 | 22 |
| 14 | West Ham UnitedWest Ham | 16 | 5 | 4 | 7 | 21 | 29 | -8 | 19 |
| 15 | Crystal Palace | 16 | 3 | 7 | 6 | 17 | 21 | -4 | 16 |
| 16 | Everton | 15 | 3 | 6 | 6 | 14 | 21 | -7 | 15 |
| 17 | Leicester CityLeicester | 16 | 3 | 5 | 8 | 21 | 34 | -13 | 14 |
| 18 | Ipswich TownIpswich | 16 | 2 | 6 | 8 | 16 | 28 | -12 | 12 |
| 19 | Wolverhampton WanderersWolves | 16 | 2 | 3 | 11 | 24 | 40 | -16 | 9 |
| 20 | Southampton | 16 | 1 | 2 | 13 | 11 | 36 | -25 | 5 |
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