Arch rivals Liverpool and Manchester United will go head to head in the last 16 of the Europa League.
The North-West enemies, who secured progression into the round last night, were paired in Friday's draw in Nyon.
The two most successful clubs in England will meet in a European competition for the first time ever when United travel to Anfield for the first leg on March 10, with the second leg scheduled at Old Trafford on March 17.
The Merseyside outfit came through their last-32 tie by sealing a 1-0 win over Augsburg on Thursday evening, while Louis van Gaal's United team overcame FC Midtjylland 5-1 at home.
Tottenham Hotspur completed the English contingent in the draw and they were paired with Borussia Dortmund - the former club of current Liverpool manager Jurgen Klopp.
Mauricio Pochettino's side, who are in contention for the Premier League title, earned their place in the last 16 following a 4-1 aggregate win over Fiorentina.
Gary Neville avoided a reunion with his former club United as his Valencia team were drawn against fellow Spanish side Athletic Bilbao.
Europa League last-16 draw in full:
Shakhtar Donetsk vs. Anderlecht
Basel vs. Sevilla
Villarreal vs. Bayer Leverkusen
Athletic Bilbao vs. Valencia
Liverpool vs. Manchester United
Sparta Prague vs. Lazio
Borussia Dortmund vs. Tottenham Hotspur
Fenerbahce vs. Braga
Germany
Switzerland
Hungary
Scotland
Spain
Italy
Croatia
Albania
England
Denmark
Slovenia
Serbia
Austria
France
Netherlands
Poland
Romania
Belgium
Slovakia
Ukraine
Portugal
Turkey
Georgia
Czech Republic