Liverpool must beat Swansea City at the Liberty Stadium if they are to avoid setting their lowest-ever points total in the Premier League era.
Meanwhile, the Swans could secure an unlikely top-half finish if they win and results elsewhere favour them. However, they could fall as low as 14th if they fail to collect maximum points.
Brendan Rodgers has no fresh injury doubts to report and is likely to name the same XI that started the 2-0 defeat to Manchester United last Sunday, with on-loan defender Steven Caulker playing his final game before returning to Tottenham Hotspur.
Reds boss Kenny Dalglish will wait before making a decision on Jose Enrique and captain Steven Gerrard, who both missed the 4-1 thrashing of Chelsea on Tuesday night.
Andy Carroll is again expected to partner Luis Suarez in attack, after the duo terrorised the Blues' defence in that match.
Charlie Adam and Lucas Leiva remain on the sidelines as long-term absentees.
Current form:
Swansea: LLWDDL
Liverpool: WLWLLW
Possible lineups:
Swansea: Vorm; Rangel, Caulker, Williams, Taylor; Allen, Gower; Dyer, Sigurdsson, Sinclair; Graham
Liverpool: Riera; Johnson, Skrtel, Agger, Jose Enrique; Kuyt, Gerrard, Spearing, Downing; Suarez, Carroll
Sports Mole says: 2-2