The champions suffered an underwhelming end to 2020 with back-to-back draws against West Bromwich Albion and Newcastle United, the latter result seeing them fail to score in the Premier League for the first time all season.

Jurgen Klopp's side do still sit three points clear at the top of the table heading into 2021, though, and they face a Southampton side that has also struggled for results lately.

Here, Sports Mole rounds up all of Liverpool's latest injury and suspension news ahead of the contest.

Joel Matip

Liverpool defender Joel Matip receives treatment for an injury on December 27, 2020 © Reuters

Status: Out
Type of injury: Adductor
Possible return date: January 21 (vs. Burnley)

Liverpool's defensive injury crisis deepened in the West Brom draw as Joel Matip suffered an adductor problem which is expected to keep him out for around three weeks.

Naby Keita

Liverpool midfielder Naby Keita walks off injured against Leicester City on November 22, 2020 © Reuters

Status: Out
Type of injury: Muscle
Possible return date: Unknown

The exact extent of Naby Keita's latest injury problem has not yet been revealed, but he is again expected to miss this match after suffering a muscle strain ahead of the draw with West Brom.

Diogo Jota

Liverpool forward Diogo Jota completes his hat-trick against Atalanta BC on November 3, 2020 © Reuters

Status: Out
Type of injury: Knee
Possible return date: February 6 (vs. Manchester City)

Diogo Jota suffered a knee injury in Liverpool's final Champions League group game - an effective dead-rubber against FC Midtjylland - and is not expected back until early February.

Kostas Tsimikas

Status: Out
Type of injury: Knee
Possible return date: February 6 (vs. Manchester City)

As bad luck would have it, Kostas Tsimikas suffered a similar injury to Jota in the very same game, meaning that he too is not expected to be back available until February.

Joe Gomez

Status: Out
Type of injury: Knee
Possible return date: Unknown

There remains hope that Joe Gomez will play again this season, but any comeback is still a while away with the centre-back still recovering from the serious knee injury he suffered in training with England.

Virgil van Dijk

Liverpool defender Virgil van Dijk walks off injured during the Merseyside derby against Everton on October 17, 2020 © Reuters

Status: Out
Type of injury: Knee
Possible return date: Unknown

Virgil van Dijk continues to offer positive updates of his recovery from the ACL injury inflicted upon him in the Merseyside derby, but it is unlikely that he will be back in time to play again this season.