The 43-year-old, who also managed Wigan Athletic and Swansea City, was sacked by the Toffees in May after three years in charge at Goodison Park.
Martinez takes over from Marc Wilmots, who left the post last month, two weeks after the Red Devils' Euro 2016 quarter-final defeat by Wales.
The vacancy for the job had been advertised online by the Belgian Football Association.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Liverpool | 12 | 10 | 1 | 1 | 24 | 8 | 16 | 31 |
| 2 | Manchester CityMan City | 12 | 7 | 2 | 3 | 22 | 17 | 5 | 23 |
| 3 | Chelsea | 12 | 6 | 4 | 2 | 23 | 14 | 9 | 22 |
| 4 | Arsenal | 12 | 6 | 4 | 2 | 21 | 12 | 9 | 22 |
| 5 | Brighton & Hove AlbionBrighton | 12 | 6 | 4 | 2 | 21 | 16 | 5 | 22 |
| 6 | Tottenham HotspurSpurs | 12 | 6 | 1 | 5 | 27 | 13 | 14 | 19 |
| 7 | Nottingham ForestNott'm Forest | 12 | 5 | 4 | 3 | 15 | 13 | 2 | 19 |
| 8 | Aston Villa | 12 | 5 | 4 | 3 | 19 | 19 | 0 | 19 |
| 9 | Fulham | 12 | 5 | 3 | 4 | 17 | 17 | 0 | 18 |
| 10 | Newcastle UnitedNewcastle | 12 | 5 | 3 | 4 | 13 | 13 | 0 | 18 |
| 11 | Brentford | 12 | 5 | 2 | 5 | 22 | 22 | 0 | 17 |
| 12 | Manchester UnitedMan Utd | 12 | 4 | 4 | 4 | 13 | 13 | 0 | 16 |
| 13 | Bournemouth | 12 | 4 | 3 | 5 | 16 | 17 | -1 | 15 |
| 14 | West Ham UnitedWest Ham | 12 | 4 | 3 | 5 | 15 | 19 | -4 | 15 |
| 15 | Everton | 12 | 2 | 5 | 5 | 10 | 17 | -7 | 11 |
| 16 | Leicester CityLeicester | 12 | 2 | 4 | 6 | 15 | 23 | -8 | 10 |
| 17 | Wolverhampton WanderersWolves | 12 | 2 | 3 | 7 | 20 | 28 | -8 | 9 |
| 18 | Ipswich TownIpswich | 12 | 1 | 6 | 5 | 13 | 23 | -10 | 9 |
| 19 | Crystal Palace | 12 | 1 | 5 | 6 | 10 | 17 | -7 | 8 |
| 20 | Southampton | 12 | 1 | 1 | 10 | 9 | 24 | -15 | 4 |
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