Barcelona head coach Hansi Flick has been hit with a late blow ahead of Sunday's La Liga clash with Valencia.
Pedri was due to take part, but he has pulled out of the squad due to an illness, so Fermin Lopez could earn a start.
Wojciech Szczesny was given the nod in goal for the Champions League clash with Benfica during the week, but the experienced stopper conceded four times during a questionable performance, and Inaki Pena is now set to be brought back into the XI.
Inigo Martinez remains unavailable for selection due to a hamstring problem, while Marc-Andre ter Stegen and Marc Bernal are long-term absentees due to serious knee injuries.
Dani Olmo was unavailable for selection against Benfica last time out due to a calf problem, and the Spain international remains unavailable for selection.
Fermin Lopez, Lamine Yamal and Raphinha could provide the support to Robert Lewandowski, who has an excellent record against Valencia. Indeed, the striker has scored six times in his four La Liga outings against Los Che.
Ronald Araujo has signed a new long-term contract with Barcelona, and the Uruguay international is again set to feature in the middle of the Catalan outfit's defence alongside Pau Cubarsi.
Barcelona possible starting lineup: Pena; Kounde, Araujo, Cubarsi, Balde; Casado, Gavi; Yamal, F Lopez, Raphinha; Lewandowski
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