England have been bowled out for 182 at the halfway stage of their fifth and final one-day international with South Africa at Trent Bridge.
Captain Alastair Cook top-scored for the hosts with a knock of 51 before he was caught and bowled by Francois du Plessis.
Jonny Bairstow (29), Craig Kieswetter (33) and Chris Woakes (33 not out) were also amongst the runs for England.
Alvaro Peterson was the tourists' most lethal player with ball thanks to his three wickets.
The bowler was on a hat-trick towards the end of the innings after getting out James Tredwell (6) and James Anderson for a golden duck.
England currently lead the series 2-1.